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KMID : 1134820230520010001
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 1 p.1 ~ p.7
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Sleep-Promoting Activity of Alcoholic Extract from Poria cocos, Longanae Arillus and Pericarpium Citri Reticulatae Viride in a Pentobarbital-Induced Sleep Model
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Park Chun-Woong
Kim Hyun-Kyung
Ahn Ye-Jin
Hong Yang-Hee
Jeon Sang-Duck
Son Seok-June
Suh Hyung-Joo
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Abstract
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The purpose of this study was to evaluate the antioxidant and sleep-promoting activities of the ethanol extracts of three medicinal plants, viz. Poria cocos, Longanae Arillus, and Pericarpium Citri Reticulatae Viride (PCRV). Polyphenol contents were analyzed by high-performance liquid chromatography and radical scavenging activity to evaluate their antioxidant activities. The sleep-promoting activities of extracts were evaluated using a pentobarbital-induced sleep model and a caffeine-induced insomnia model. Of the three medicinal plant extracts, PCRV extract had the highest total polyphenol content (215.44 mg/g) and exhibited excellent radical scavenging activity. Furthermore, PCRV extract contained sleep-promoting quercetin-3-glucuronide and trans-ferulic acid and promoted sleep more than the other two extracts, and at 160 or 200 mg/kg, PCRV extract also more significantly improved sleep latency (P<0.001) and duration (P<0.001). In the insomnia model, caffeine-induced increases in sleep latency and reductions in sleep duration were significantly and dose-dependently suppressed by PCRV extract. Collectively, the study shows PCRV extract effectively removes free radicals, promotes sleep, and has potential use as a functional substance for ameliorating sleep disorders.
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KEYWORD
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pentobarbital-induced sleep, Poria cocos, Longanae Arillus, Pericarpium Citri Reticulatae Viride
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